Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B
نویسندگان
چکیده
منابع مشابه
Novel Genetic Variants of Hepatitis B Virus in Fulminant Hepatitis
Fulminant hepatitis (FH) is a life-threatening liver disease characterised by intense immune attack and massive liver cell death. The common precore stop codon mutation of hepatitis B virus (HBV), A1896, is frequently associated with FH, but lacks specificity. This study attempts to uncover all possible viral nucleotides that are specifically associated with FH through a compiled sequence analy...
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background hepatitis b virus (hbv) infection is a serious public health problem in china and worldwide. mother-to-child transmission is one of hbv’s main transmission routes in highly endemic regions. genome-wide association studies (gwas) identify single nucleotide polymorphisms (snps) at hla loci as associated with hbv infection. however, the mechanisms of hbv perinatal transmission and break...
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MicroRNAs are small non coding RNAs that are involved in gene expression regulation. Mir-122 was reported to inhibit hepatitis B virus (HBV), but little is known about the role of mir-122 polymorphisms on HBV infection development. This present study aimed to investigate the association between single nucleotide polymorphisms (SNPs) in mir-122 gene region with HBV infection. Study cases were HB...
متن کاملHost Genetic Variants in HLA Loci Influence Risk for Hepatitis B Virus Infection in Children
BACKGROUND Hepatitis B virus (HBV) infection is a serious public health problem in China and worldwide. Mother-to-child transmission is one of HBV's main transmission routes in highly endemic regions. Genome-wide association studies (GWAS) identify single nucleotide polymorphisms (SNPs) at HLA loci as associated with HBV infection. However, the mechanisms of HBV perinatal transmission and break...
متن کاملYMDD and FLLAQ Mutations in Chronic Hepatitis B Patients
Abstract Background and Objective: Lamivudine is the first orally available drug approved for treatment of chronic hepatitis B. Mutations at the YMDD and FLLAQ motifs in the domains of HBV polymerase gene contribute resistance to lamivudine. This study was aimed to determine the rate of YMDD and FLLAQ mutants in hepatitis B patients in Golestan Province, Iran. Material and methods: In this cros...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2015
ISSN: 0270-9139,1527-3350
DOI: 10.1002/hep.27794